Over the past five years, Dr. Safieddine’s team has focused its efforts on the development of viral gene therapy as a potential curative treatment for inherited human deafness. The team first identified a viral vector specifically targeting cochlear and vestibular sensory cells. Using this vector in gene therapy, the team was able to restore hearing in a mouse model of human deafness DFNB59. The team has also successfully restored both hearing and balance in a mouse model of Usher 1G syndrome. The last breakthrough accomplished by Dr Safieddine’s team is the restoration of hearing in an adult mouse model of DFNB9 deafness.