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Pasteur Institute


Over the past five years, Dr. Safieddine’s team has focused its efforts on the development of viral gene therapy as a potential curative treatment for inherited human deafness. The team first identified a viral vector specifically targeting cochlear and vestibular sensory cells. Using this vector in gene therapy, the team was able to restore hearing in a mouse model of human deafness DFNB59. The team has also successfully restored both hearing and balance in a mouse model of Usher 1G syndrome. The last breakthrough accomplished by Dr Safieddine’s team is the restoration of hearing in an adult mouse model of DFNB9 deafness.

Job position

Researcher in Hearing Genetic and physiology unit